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21(35):5483-95
EPZ-6438 inhibits EZH2 in a manner competitive with the substrate S-adenosylmethionine (SAM)
including USP2
PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation
GNF7156 is a good chemical tool to support the feasibility of treating diabetes with an oral therapy to restore β-cell mass
Bromosporine - Pan-bromodomain Inhibitor. CAS# 1619994-69-2 istone Demethylase 21(35):5483-95Bromosporine, CAS No. 1619994 69 2, is a broad spectrum inhibitor for bromodomains with IC50 of 0. 41 M, 0. 29 M, 0. 122 M and 0. 017 M for BRD2, BRD4, BRD9 and CECR2, respectively. In cell based assays, Bromosporine (1 M) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1, BAZ2A, and SMARCA2 (at 10 M). Bromosporine shows moderate cytotoxicity in HeLa cells at 18 M. It is a very useful chemical probe for bromodomain
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