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(2009) J Med Chem
Eur Spine J
56-39)40(48)41(49)45-16-12-11-13-32(45)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-31(44)35(22-29)52-7/h18
YCN47284 was first reported in WO 9621450
resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB
Danusertib (PHA-739358) Catalog No.:M7725-10 (2009) J Med ChemDanusertib, also known as PHA 739358, is a small molecule 3 aminopyrazole derivative with potential antineoplastic activity. Aurora kinase inhibitor PHA 739358 binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed. This agent may preferentially bind to and inhibit Aurora B kinase. Aurora kinases, a family of serine threonine kinases, are important
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