MLN8237 (Alisertib) - Aurora A inhibitor. CAS# 1028486-01-2 60125 Smiles: N#CC1C=C(N=CC=1)N1[C@@H](CCC1=O)C(=O)N([C@@H](C1=CC=CC=C1Cl)C(=O)NC1CC(F)(F)C1)C1=CC(F)=CN=C1

Smiles: N#CC1C=C(N=CC=1)N1[C@@H](CCC1=O)C(=O)N([C@@H](C1=CC=CC=C1Cl)C(=O)NC1CC(F)(F)C1)C1=CC(F)=CN=C1

Chemical Name: N-(6-((2S

Formula: C23H20O3

Chem Pharm Bull (Tokyo)

UNC1215 was used to reveal a new Kme-dependent interaction of L3MBTL3 with BCLAF1

MLN8237 (Alisertib) - Aurora A inhibitor. CAS# 1028486-01-2 60125 Smiles: N#CC1C=C(N=CC=1)N1[C@@H](CCC1=O)C(=O)N([C@@H](C1=CC=CC=C1Cl)C(=O)NC1CC(F)(F)C1)C1=CC(F)=CN=C1MLN8237 (Alisertib), CAS No. 1028486 01 2, is a highly potent and selective Aurora A inhibitor with an IC50 of 1. 2 nM, >200 fold selective towards structurally related Aurora B (IC50 of 396. 5 nM). It does not have any significant activity against 205 other kinases. MLN8237 treatment inhibits the phosphorylation of Aurora A in MM1. S and OPM1 cells, without affecting the Aurora B mediated histone H3 phosphorylation. MLN8237 significantly inhibits