L-873724 ressin acetate 4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

InChi: InChI=1S/C12H18N2O

4-Di-O-caffeoylquinic acid

Preformed capsids are stabilized by BAY 41-4109

Measurement of proliferation following treatment with Larotrectinib (LOXO-101) demonstrates a dose-dependent inhibition of cell proliferation in all three cell lines

L-873724 ressin acetate 4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrileL 873724 is a potent, orally bioavailable, selective and reversible non basic cathepsin K inhibitor, with IC50s of 0. 2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively. L 873724 also exhibits an IC50 of 0. 5 nM for rabbit cathepsin K. L 873724 inhibits bone resorption. Product information CAS Number: 603139 12 4 Molecular Weight: 481. 53 Formula: C23H26F3N3O3S Chemical Name: (2S) N (cyanomethyl) 4 methyl 2