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The place this shows up most is on effects that change power and toughness both temporarily and permanently

Malcolm's combat damage trigger takes place after damage, meaning that by that point, +2/+0 won't matter, and it will be too late to draw a card with Captain HowlerCaptain Howler's own combat damage trigger

Pretty good for four mana

Mizzix gains an experience counter every time you cast an instant or sorcery with mana value greater than the number of experience counters, and it gives you a discount on your instants and sorceries per experience counter it has